Where Hyde Park London When 11 July How much £

first_imgWhere: Hyde Park, LondonWhen: 11 JulyHow much: £54What: Reunion concert celebrating 25 years of mega-selling pop producers Stock, Aitken and Waterman.Who: Steps, Sonia, Bananarama, Brother Beyond, Rick Astley, 2 Unlimited, Pepsi & ShirleyWhy: If that line-up is not enough to have you salivating with excitement, it’ll be worth going just to see Kylie & Jason duet on ‘Especially for You’.2. DownloadWhere: Donington Park, EnglandWhen: 8-10 JuneHow much: £190What: The UK’s must-do fest for the connoisseur of serious rock and metal.Who: Black Sabbath, Megadeth and… Sebastian BachWhy: To see Sebastian Bach perform his ‘Concerto for Two Violins in D Minor’ (er, I think there’s been some mistake – Ed)3. T in the ParkWhere: Perthshire, ScotlandWhen: 6-8 JulyHow much: £189What: One of the UK’s biggest music festivals with a line-up embracing rock, pop and dance.Who: Snow Patrol, David Guetta, Nicki Minaj and… Simple MindsWhy: A good excuse to drink lager for three days, and throw tomatoes at Cher Lloyd. 4. CreamfieldsWhere: Cheshire, EnglandWhen: 24-26 AugustHow much: £135What: A veritable who’s who of electronic dance music DJs and acts.Who: Tiësto, Paul van Dyk, deadmau5Why: If, as The Beach Boys once sang, you’ve got to ‘dance, dance, dance, ‘cos the beat’s really hot’, this is the fest for you – there’ll be more beats than a Scottish salmon river. Don’t forget your glowsticks.5. GlastonbudgetWhere: Leicestershire, EnglandWhen: 1-3 JuneHow much: £62What: Not just a bad pun, but a festival specialising in tribute bands.Who: The Kinx, The Police Academy, Who’s who, This is Nirvana etc, etcWhy: Even better than the real thing? It’s unlikely that they’ll ever be a line-up featuring The Kinks, The Police, The Who and Nirvana.Mainland Europe6. Rock Wechter Where: Leuven, BelgiumWhen: 28 June – 1 JulyHow much: 195 eurosWhat: Mega rock festival (if that wasn’t obvious) with heavyweight line-up.Who: Red Hot Chili Peppers, Blink 182, Pearl JamWhy: They have published all the times that bands are on stage already, so you don’t have to fork out even more cash on one of those lanyard thingys. 7. Rock Am RingWhere: 1-3 JuneWhen: Nürburgring, GermanyHow much: 175 eurosWhat: European rock festival behemoth.Who: Metallica, Cypress Hill, Tenacious D and… Dick Brave & the BackbeatsWhy: A must-do for the long and straggly of hair. You’re not a real rock fan if you’re not wearing your Rock Am Ring wristband.8. RoskildeWhere: Roskilde, DenmarkWhen: 5-8 JulyHow much: 240 eurosWhat: Massive, famous music festival, once graced by Status QuoWho: Bruce Springsteen, The Cure, Björk and… Hank Williams IIIWhy: To witness/take part in the annual Nude Run, the male and female winners of which win a ticket for next year.9. SzigetWhere: Budapest, HungaryWhen: 6-13 AugustHow much: 195 eurosWhat: Europe’s biggest music festival, held on an island in the Danube.Who: Korn, Placebo, Ministry and… Chef’SpecialWhy: It goes on for a whole week (if that’s a good thing), and boasts ‘an electronically amplified, warped amusement park that has nothing to do with reality’.10. Primavera SoundWhere: Porto, PortugalWhen: 7-10 JuneHow much: 99 eurosWhat: Indie-friendly festival held in a park in the lovely city of Porto.Who: Suede, St. Etienne, SpiritualizedWhy: If only because Sleepy Sun are playing – a band to see after a few sherries if ever there was one.11. PohodaWhere: Trencin, SlovakiaWhen: 5-7 JulyHow much: 85 eurosWhat: Family-friendly fest featuring big names in rock, pop and danceWho: Public Enemy, Kasabian and… The Maggie’s MarshmallowsWhy: It’s free for kids, and there’s a special children’s park where you can leave your offspring while you mosh to The Offspring. Not that they’re playing.12. BenicassimWhere: Valencia , SpainWhen: 12-14 JulyHow much: £155What: Big music festival by the beach between Barcelona and Valencia. One of the most popular European fests for Brits.Who: David Guetta, Stone Roses, Dizzee Rascal and… Kurt Vile & the ViolatorsWhy: All your favourite acts that are picking up their paychecks at every other festival, plus sunshine, and the beer, is much cheaper than at home.13. ExitWhere: Novi Sad, SerbiaWhen: 12-15 JulyHow much: £95What: Hedonistic festival held in the grounds of a fortressWho: Guns N’ Roses and… Duran Duran and… Totally Enormous Extinct DinosaursWhy: Rated as one of the best festival experiences in the world, partly thanks to its unique setting.14. MetaltownWhere: Gothenburg, SwedenWhen: 15-16 JuneHow much: £149What: Metal, metal and more metal (like, duh, what were you expecting, The Carpenters?)Who: Slayer, Marilyn MansonWhy: Just so you can attempt to say ‘I’m going to Metaltown’ while keeping a straight face.15. OutlookWhere: Pula, Croatia When: 30 August – 2 SeptemberHow much: £120What: A Club 18-30 holiday for the dubstep generationWho: Skream, Goldie, Zion Train, Congo NattyWhy: Ibiza is so 199516. Hellfest Where: Clisson, FranceWhen: 15-17 JuneHow much: 149 eurosWhat: Well, from the name you may have deduced that it’s not a family-friendly event featuring magicians and story-telling tentsWho: A who’s who of metal from Cannibal Corpse to Napalm Death and… too many meant-to-be-scary-but-actually-ridiculously-stupidly-named bands to mention, from Big Business to Sublime Cadaveric Decomposition.Why: So you can tell your mum you saw Sublime Cadaveric Decomposition.The rest of the world18. Coachella Glastonbury isn’t on this year, but there are plenty of alternatives for the music festival-goer in the UK, Europe and the rest of the world. Here are 20 of the biggest, the best and the craziest. Rock on!UK1. Hit Factory Live Related20 best music festivals 2014Forget Reading. How about Hellfest? 20 of the biggest, best and craziest music festivals in the world in 2014.20 best music festivals 2013Forget Reading. How about Hellfest? 20 of the biggest, best and the craziest music festivals in the world.13 of the best music festivals for 2015Find the soundtrack to your summer at one of these incredible international music festivals. Where: Indio, California, USAWhen: 13-15 and 20-22 AprilHow much: $285What: The American GlastonburyWho: Dr. Dre & Snoop Dogg, Arctic Monkeys, The Black KeysWhy: To hang out backstage with Paris Hilton.19. ShambhalaWhere: Nelson, British Columbia, CanadaWhen: 10-13 AugustHow much: $280What: Not for the faint-hearted! Hippy electronic music festival held on a cattle ranch in the Canadian RockiesWho: tbcWhy: It’s a family-run, non-corporate event enjoying a stunning natural location.20. Fuji RockWhere: Naeba, Niigata, JapanWhen: 27-29 JulyHow much: £338What: Japan’s largest outdoor music event with an amazing setting in the mountains, with forests and rivers between stages, and a cable car.Who: The Specials, Radiohead, Elvis CostelloWhy: For a festival experience so utterly different to Reading or V. For example, their website advises not to go near the bees’ nests. Watch out for the snakes, and the bears!ReturnOne wayMulti-cityFromAdd nearby airports ToAdd nearby airportsDepart14/08/2019Return21/08/2019Cabin Class & Travellers1 adult, EconomyDirect flights onlySearch flights Maplast_img read more

Rice breakthrough could prevent multiple fibrotic diseases

first_imgShareRICE UNIVERSITY CONTACT:  Jade BoydPHONE: 713-348-6778E-MAIL: jadeboyd@rice.edu    PROMEDIOR, INC. CONTACT: Tim Pelura, CEOPHONE: 610-560-1435E-MAIL: tpelura@promedior.comRice breakthrough could prevent multiple fibrotic diseasesTests find protein stops formation of life-threatening scar tissueA scientific breakthrough at Rice University could lead to the first treatment that prevents the build-up of deadly scar tissue in a broad class of diseases that account for an estimated 45 percent of U.S. deaths each year.“Fibrotic diseases kill so many people because they can crop up in almost any part of the body, and cardiac fibrosis is a particular problem for anyone who’s had a heart attack,” said Richard Gomer, professor of biochemistry and cell biology at Rice. “We’ve discovered a naturally occurring blood protein that prevents dangerous scar tissue from forming.”The protein, which is called serum amyloid P, or SAP, has proven effective at preventing fibrotic disease from developing in the hearts of lab animals, and Gomer and colleagues hope it will eventually save thousands of lives once it is developed for human use.Fibrosis occurs when the body’s natural healing process goes awry, creating extra scar tissue that does more harm than good. There are dozens of fibrotic diseases, including atherosclerosis, asthma, cirrhosis, scleroderma and pulmonary fibrosis. Since there are no FDA-approved treatments to prevent fibrotic tissue from forming, doctors typically consider fibrosis to be an irreversible process, and they try to slow it as much as possible with anti-inflammatory and immunosuppressive drugs.The biopharmaceutical company Promedior Inc., of Malvern, Pa., has licensed Rice’s SAP technology for use against fibrotic diseases. The company is engaged in animal testing, but has not yet set a date for the first human clinical trials of SAP.Gomer said initial animal tests of SAP at Rice have proven very promising. Their first study, published in the Proceedings of the National Academies of Science in November with collaborators at Baylor College of Medicine, found that SAP injections prevented the formation of fibrotic scar tissue in the hearts of lab animals. Publication of results on the first pulmonary fibrosis tests of SAP is expected soon, Gomer said.Gomer said SAP is a naturally occurring protein that circulates in the bloodstream and plays a crucial role in regulating wound healing. SAP’s role is to inhibit the activity of immune cells called fibrocytes, which make excess collagen that the body uses to heal wounds. Gomer said the tests at Rice show that maintaining an elevated level of SAP in the blood is enough to prevent fibrotic diseases from forming.He said SAP research in his lab began in 2001 after a chance meeting between himself and UK immunologist Darrell Pilling. Gomer, who’d spent most of his career studying the single-celled amoebae Dictyostelium, met Pilling at lunch during a cell biology conference. Pilling, who was a post-doctoral research fellow at the University of Birmingham in the UK, had recently identified the factor that promoted lymphocyte survival in the fibrotic joints of rheumatoid arthritis patients. However, Pilling was hoping to isolate novel biochemical factors associated with high cell density survival, and Gomer suggested he come to Houston to test some techniques that had proven useful with Dictyostelium. A few days after arriving, the pair noticed a clear interaction between the presence of serum and fibrocytes, and within months had isolated the active component as SAP.They immediately recognized the importance of the find: Pilling stayed in Houston as a faculty fellow, and Gomer all but abandoned his internationally recognized work on Dictyostelium. He even quit tinkering with astronomical research gear, a passion he’d nurtured since his days as an undergraduate physics major that allowed him to co-author a number of astrophysical research papers over the years.“Astronomy is a lot of fun, but I just couldn’t see myself spending the time on it when thousands of people were dying every day from these diseases,” Gomer said.Gomer and Pilling’s research is funded by the NIH, and was also funded by the Howard Hughes Medical Institute and the Scleroderma Foundation. AddThislast_img read more