a month agoTottenham see Southgate as top replacement for Pochettino

first_imgTottenham see Southgate as top replacement for Pochettinoby Paul Vegasa month agoSend to a friendShare the loveTottenham see England boss Gareth Southgate as their top replacement for Mauricio Pochettino if the Argentine quits the club.Spurs chiefs believe Southgate’s relationship with the club’s England stars would make him the ideal successor to Pochettino, who increasingly looks as though he is in his last season at Tottenham, says the Mirror.Pochettino said before last season’s Champions League final that he could might leave if Tottenham lifted the European Cup – as it would have been the culmination of a five-year project.And speculation Real Madrid will come in for him refuses to go away, with Bernabeu boss Zinedine Zidane already feeling the pressure after returning to the La Liga giants.Harry Kane, Dele Alli, Harry Winks, Danny Rose and Eric Dier have all made huge strides with England under Southgate’s tutelage.And that made him the perfect candidate when Pochettino’s comments in the lead-up to the Champions League final forced Spurs chairman Daniel Levy to consider potential replacements. TagsTransfersAbout the authorPaul VegasShare the loveHave your saylast_img read more

Earlycareer job loss has long term health implications

first_imgReviewed by James Ives, M.Psych. (Editor)Feb 20 2019Sociologists at the University of Bamberg analyze employment biographiesNumerous studies have suggested that job loss and unemployment lead to poorer health. Sociologists at the University of Bamberg are now continuing this research and have set out to answer whether job loss still has health-related consequences even if it occurred decades ago and subsequent employment may have been found. Jonas Voβemer and Professor Michael Gebel, Chair of Methods of Empirical Social Research at the University of Bamberg, have shown with their current research that involuntary loss of employment early in a person’s career has long term health implications. Even more than 30 years later, negative health impacts can be traced back to early-career job loss.Related StoriesBridging the Gaps to Advance Research in the Cannabis IndustryTrump administration cracks down on fetal tissue researchOlympus launches next-generation X Line objectives for clinical, research applicationsFor their study, the researchers used data from the SHARELIFE survey which is the third wave of the Survey of Health, Ageing and Retirement in Europe (SHARE). The transnational study interviewed approximately 28,000 Europeans over the age of 50 about their social and familial networks, health, and socio-economic status over the course of their lives. The analyses, carried out by Voβemer and Gebel in cooperation with Dr. Olena Nizalova of the University of Kent in England and Olga Nikolaieva of the Kyiv School of Economics in Ukraine, reveal that people who involuntarily lost their jobs within the first ten years of their professional lives were on average 6 percentage points more likely to rate their own health as fair or poor compared to those who had not experienced a loss of employment in the same phase, but had otherwise similar characteristics.The researchers were also able to show that the effects were the same for employees who were laid off and for those whose jobs were lost due to plant closures. This suggests that the data analyses could avoid the effects of confounding factors, because in the case of a plant closure, all employees are affected and it is less likely that the job loss could be explained by personal characteristics that would also affect health. So what conclusions can be drawn from these findings? Voβemer says, “Consistent with earlier studies, we have shown that losing a job and periods of unemployment have more than just financial consequences. Moreover, our study indicates that these consequences may be long lasting.” These findings, if replicated in future studies, suggest that policy makers should consider both health implications and their persistence when evaluating the costs of job loss and unemployment.The study is part of the international and interdisciplinary EXCEPT project (Social Exclusion of Youth in Europe: Cumulative Disadvantage, Coping Strategies, Effective Policies and Transfer) which received approximately 2.4 million euros in funding from the European Union. Source:https://www.uni-bamberg.de/en/last_img read more

Targeted treatment offers symptom relief for patients with psychosis

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Jul 3 2019Treatment for individuals who experience psychosis, such as hallucinations and delusions as a result of a psychiatric illness, can be targeted to a specific structural mutation, according to a study published by researchers from McLean Hospital and other institutions in the journal Biological Psychiatry.The study was led by Deborah L. Levy, PhD, director of the Psychology Research Laboratory at McLean Hospital, the largest psychiatric affiliate of Harvard Medical School. The research provides a proof-of-principle demonstration of symptom relief by targeting a specific genotype and links an individual structural mutation to the pathophysiology of psychosis and treatment response.In the last decade, significant progress has been made in identifying genetic factors underlying schizophrenia, bipolar disorder, and other psychiatric disorders. Hundreds if not thousands of common genetic variants are collective risk factors for schizophrenia and other psychotic disorders. However, the impact of each individual variant is both very small and indecisive in determining risk.Rare genetic variants, on the other hand, can have large effects on risk. These variants are thus assumed to impact core pathophysiological processes.Large-effect mutations are individually rare, with even the most recurrent impacting relatively few individuals. Some are so rare that they are private mutations, known to occur in only one or a few families, as is the mutation described by Levy and her colleagues.Levy’s study describes a variant that is characterized by an increase in the number of copies of specific genes (i.e., a copy number variant or CNV). In this case, is effectively due to the presence of a small extra chromosome. This CNV includes the gene encoding the enzyme glycine decarboxylase (GLDC). “The compelling aspect is that this CNV can be linked to pathophysiology, and, as the new study shows, to treatment,” said Levy.GLDC breaks down glycine, which is a co-agonist at the NMDA receptor, a type of excitatory glutamate receptor. The patients in this study have four, instead of the usual two, copies of the GLDC gene. Source:McLean Hospital We thus predicted that they would have increased glycine breakdown and thus less glycine available at the glycine modulatory site of the NMDA receptor. This results in NMDA receptor hypofunction.”Uwe Rudolph, MD, former director of the Laboratory of Genetic Neuropharmacology at McLean Hospital The present study illustrates that targeting structural genetic variants is a promising approach but because these variants are individually rare, most studies will have very small sample sizes, complicating the usual approach to statistical analysis.” Nevertheless, she said, “Because the effects of a targeted treatment can be large, it is important to prioritize opportunities to study even small groups of patients who may benefit.” NMDA receptor hypofunction has long been considered an important factor in the pathophysiology of schizophrenia. Variants in genes associated with NMDA receptor function are overrepresented in schizophrenia.According to Levy, the presence of an increased number of copies of GLDC raised the question of whether this CNV is medically actionable in individuals with this mutation.Related Stories$10 million endowed gift supports psychosis research effortsGeorgia researcher receives grant to develop models to better predict mental health disordersResearch on cannabis use in women limited, finds new study”Starting with individual carriers of the mutation, meaning using a ‘genotype-first’ approach, we sought to determine whether the predicted reduced glycine availability attributable to the increased copy number could be potentially normalized with agents that increase glycine or D-serine availability,” explained Levy. “This approach contrasts with the usual standard clinical practice of treating individuals on the basis of clinical symptoms or diagnosis independent of specific genetic variants.”Participants in the study had four identical copies of the GLDC gene. The authors showed that supplementation of standard psychotropic agents (including clozapine) with glycine or D-cycloserine (a partial selective agonist at the NMDA receptor) resulted in improvement in clinical symptoms. The researchers provided two independent proof-of-principle demonstrations of symptom relief by targeting this specific genotype.Notably, the same rare mutation occurred here in different clinical disorders (schizoaffective disorder and bipolar disorder with psychotic features). This suggest that treatment response was determined by the targeted mutation independently of clinical diagnosis.”It is important to note that the two subjects studied here bore little clinical resemblance, with distinctly different symptom burdens, and highly dissimilar courses of illness,” noted J. Alexander Bodkin, MD. Bodkin, the director of the Clinical Psychopharmacology Research Program at McLean, oversaw psychiatric care of both subjects throughout the blinded and open-label trials of glycine and d-cycloserine.”The findings may implicate a ‘molecular subtype’ that may respond to treatments that normalize dysregulation of the glutamatergic system” said Levy, “Specifically, carriers of other related mutations may potentially benefit from low-dose D-cycloserine as well. If it becomes possible one day to identify patients with such molecular subtypes in clinical practice, studies could be conducted that would potentially make targeted treatment approaches available to a larger group of patients.”Moreover, one of the study’s authors, Charity J. Morgan, PhD, University of Alabama at Birmingham, stated:last_img read more

Not a social media influencer You can still get paid

first_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Not a social media influencer? You can still get paid (2018, September 27) retrieved 17 July 2019 from https://phys.org/news/2018-09-social-media-paid.html Glazier says it shouldn’t be so hard to make money from your recommendations. And you shouldn’t have to be internet-famous to get paid when you directly encourage a sale, he says.”You don’t have to be an influencer to have influence,” Glazier said.HOW IT WORKSAnyone can download the Wildlink app for free (available on Android, iOS, or as a software download for your computer). It runs in the background while you go about your business. Then, let’s say you post a picture of yourself on Facebook, and a friend replies, “I love your dress. Where did you buy it?” If you reply with a link to the dress on Nordstrom’s website, then Wildlink’s app will convert that URL to a trackable link. If your friend follows that link and eventually purchases the item, you get a commission that’s paid to a virtual wallet.Once a month, you can cash out your Wildlink commissions to your PayPal account.The company, which is working out of the Connect coworking space in University City, has built several ways to make this process seamless for the user. For example, once you download the app, its technology is built into your cell phone’s keyboard. The software can then guess when you’re typing a brand name, product, or service. Once you type out the word “REI,” for example, the software gives you an option to insert a link to REI directly from your keyboard.WHAT ABOUT PRIVACY?Warning bells may be ringing for the privacy-conscious. Will Wildfire now be reading my text messages, emails, and social media posts? Glazier says no. The software runs on your device, and it’s only searching for brands that match with its database of merchants. And the user always has the option of generating a link or ignoring the software’s suggestion.But Wildfire may have to deal with other concerns. For example, will a friend’s recommendation lose its power of influence if it’s known that they’re making a commission off the recommendation?Miro Copic, a marketing professor at San Diego State University, says there’s a big transition going on in the influencer space in which fans want transparency from the influencers they follow about their economic incentives.. Fans and followers want those individuals to be transparent about the economic incentives they’re getting to pitch a product.”The nuance here is disclosure,” Copic said. “Not that your friend won’t be your friend anymore, but they might question your motives if they find out you’re being compensated for your suggestions.”Malcolm Bohm, CEO at a company called Liquid Grids in San Diego, has been working in a similar space for years. His company also uses natural language processing to understand what internet users are saying on health forums, and how it relates to brands.Bohm says Wildfire could be onto something big, but it’s critical that they maintain transparency along the way”At the grassroots level, this could be disruptive in terms of how brands get recommendations,” Bohm said. “As long as they maintain authenticity, it could be really positive.”Glazier said Wildlink asks users to disclose this information themselves, notifying friends and family that they might be compensated for their recommendations.”In our terms of service we require that people follow the guidelines, but it’s really up to them to do so,” Glazier said.NEXT STEPSWildfire has received $2 million in seed money, led by Santa Monica-based investor group Mucker Capital in 2017. The company plans to raise another round of financing this fall, and will use those funds to expand its marketing and business development team in San Diego. Don’t try to make money off my online behavior—unless, of course, I get a commission. ©2018 The San Diego Union-Tribune Distributed by Tribune Content Agency, LLC.center_img A new app pays you for product recommendations Explore further That’s the idea behind San Diego tech startup Wildfire Systems, which is launching an app to help internet users make money off of conversations they’re already having online. The local company, founded by a former eBay executive, lets users earn commissions from recommendations they share on the Internet, whether it’s on social media, by email, or through text messaging apps.If, for example, a friend buys an Instant Pot after you raved about the pressure cooker on Instagram, then this startup’s software would let you get a cut of the sale.The idea is particularly timely considering the public outcry against tech giants like Facebook, who’ve been lambasted in recent months for making money off their users’ activity and personal data.Now, merchants are tripping over themselves to sign onto Wildfire’s platform, which already has 20,000 retailers on board, including giants like Expedia, Nordstrom’s, REI, and Walmart.The quick adoption may have something to do with the startup’s CEO, Jordan Glazier, who founded Wildfire Systems last year. Glazier is best known locally for leading a San Diego company called Eventful, which gained some fame a few years ago as the first global events calendar online. He grew that company to more than 25 million users before selling it to CBS in 2014. Before that, he was an early employee at eBay, where he helped transform the company from a collectibles website to the e-commerce giant it is today.WE’RE ALL INFLUENCERS?Glazier’s new app, Wildlink, brings to mind the marketing tactics that bloggers and other folks of online fame use, in which they get kickbacks from brands for pitching products online.In the industry, this is called “affiliate marketing,” and it’s a tool mostly used by people who have large followings on social media (collectively known as “influencers”). But it’s not so easy to make money this way. People have to sign up for individual affiliate marketing programs depending on the brand or retailer and then jump through hoops for each one before they can start earning cash.last_img read more

The Marshall Islands Are 10 Times More Radioactive Than Chernobyl

first_img Originally published on Live Science. The researchers tested coconuts and pandanus fruit (shown here) for radioactivity on 11 of the islands. Credit: Shutterstock 10 Times HBO’s ‘Chernobyl’ Got the Science Wrong In Photos: World’s 10 Most Polluted Places In Photos: Fukushima Butterflies Plagued With Defects Some of the Marshall Islands in the Pacific Ocean — such as the Bikini and Enewetak atolls — are still more radioactive than Chernobyl and Fukushima, even though more than 60 years have passed since the United States tested radioactive weapons on those islands, a new study finds. When testing the soil for plutonium-239 and -240, the researchers found that some of the islands had levels that were between 10 and 1,000 times higher than those on Fukushima (where an earthquake and tsunami led to the meltdown of nuclear reactors) and about 10 times higher than levels in the Chernobyl exclusion zone. The researchers took only a limited number of soil samples, meaning a more comprehensive survey is needed, they said. Regardless, they were surprised that neither national governments nor international organizations had “any further guidance on permissible plutonium levels in the soil,” even though levels in the Marshall Islands were high, the researchers wrote in the study. [Top 10 Greatest Explosions Ever]These Sharks Were Too Busy to Notice a Bigger Predator Watching ThemThe unexpected twist at the end of this feeding frenzy delighted scientists.Credit: NOAA Office of Ocean Exploration and Research, Windows to the Deep 2019Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Headbutting Tiny Worms Are Really, Really Loud00:35关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接https://www.livescience.com/65949-marshall-islands-more-radioactivity-chernobyl.html?jwsource=cl已复制直播00:0002:2802:28  Testing bombs After dropping atomic bombs on the Japanese cities of Hiroshima and Nagasaki in 1945, effectively ending World War II, the United States decided to test more radioactive weapons. Some of these tests happened in the Marshall Islands, a chain of islands between Hawaii and the Philippines that was then a district of the Trust Territory of the Pacific Islands and was run by the U.S. on behalf of the United Nations. The first two bombs, called Able and Baker, were tested on Bikini Atoll in 1946 and kicked off a 12-year period of nuclear testing on the Bikini and Enewetak atolls, during which the U.S. tested 67 nuclear weapons. The first-ever hydrogen bomb test, with the code name Ivy Mike, was tested on Enewetak in 1951. The U.S. conducted its largest hydrogen bomb test on Bikini Atoll — the 1954 Castle Bravo bomb, which was more than 1,000 times more powerful than Little Boy, the uranium weapon that decimated Hiroshima. In addition to contaminating the Bikini and Enewetak atolls, nuclear fallout from the tests also rained down on and sickened people living on Rongelap and Utirik atolls (also part of the Marshall Islands), the researchers said. In 2016, a team of researchers from Columbia University in New York published a study in the journal Proceedings of the National Academy of Sciences (PNAS) on the background gamma radiation in three of the northern Marshall atolls: Enewetak, Bikini and Rongelap. The researchers found that radiation levels on Bikini were higher than previously reported, so they decided to do more in-depth studies on radioactivity in the islands. (Nuclear weapons are one source that releases gamma-rays, which are like energetic X-rays.) More fallout Now, that same team has written three new studies, published online yesterday (July 15) in the journal PNAS, on four of the atolls in the northern Marshall islands: Bikini, Enewetak, Rongelap and Utirik. External gamma radiation levels were significantly elevated on Bikini Atoll, on Enjebi Island in Enewetak Atoll and on Naen Island in Rongelap Atoll, compared with an island in the southern Marshall Islands that the scientists used as a control, the researchers found. The levels on Bikini and Naen islands were so high, they surpassed the maximum exposure limit that the United States and the Republic of the Marshall Islands agreed to in the 1990s, the researchers said. (On a side note, bikini swimsuits weren’t named after the island because of its tropicality, but because the French designer wanted the two-piece swimsuit to be “explosive,” just like the bomb tested there, said one of the study’s senior scientists, Ivana Nikolic-Hughes, director of the K1 Project at the Center for Nuclear Studies and a senior lecturer of chemistry at Columbia University.) [Flying Saucers to Mind Control: 22 Declassified Military & CIA Secrets] The researchers also found that the islands of Runit and Enjebi in Enewetak Atoll, as well as on Bikini and Naen islands, had high concentrations of certain radioactive isotopes in the soil. (An isotope is an element with a different number of neutrons in its nucleus.) These four islands had radioactive plutonium levels that were higher than those found in Fukushima and Chernobyl, the researchers found. “What was surprising was just how high the external gamma radiation was for Naen, which is the outer island for Rongelap Atoll,” Nikolic-Hughes told Live Science. “It was populated during the Bravo test … [the people there] were then moved, moved back and moved again. It’s quite a dreadful history of what happened to Rongelapese people.” In their second study, the researchers worked with professional divers, who collected 130 soil samples from the Castle Bravo Crater at Bikini Atoll. The level of some of the isotopes — plutonium-239 and -240, americium-241 and bismuth-207 — was an order of magnitude higher than levels found on other Marshall Islands, the researchers found. These findings are important because “measuring the radioactive contamination of the crater sediment is a first step in assessing the overall impact of nuclear weapons testing on the ocean ecosystems,” the researchers wrote in the study. In the third study, the researchers tested more than 200 fruits — mostly coconuts and pandanus — on 11 of the islands from four different atolls in the northern Marshall Islands. Cesium-137 levels didn’t look good for a sizeable chunk of the fruits on Bikini and Rongelap atolls, which had radioactivity levels higher than those deemed safe by several countries and international organizations, the researchers found. More work is needed to educate people living on the Marshall Islands about these dangers. Moreover, these findings and future research can shed light on whether it’s safe for the Marshallese people to resettle or harvest food on some of these islands, the researchers said.last_img read more

POCSO Act amended Death penalty for child sex abuse

first_imgOur kids are not safe online SHARE SHARE EMAIL COMMENT crime SHARE COMMENTS Kathua gang rape: 3 get life imprisonment, 3 others 5 years’ jail term RELATED July 10, 2019 Amendment to POCSO Act gets nod The government, in a statement, said the amendments in Section-2, 4, 5, 6, 9, 14, 15, 34,42 and 45 of the POCSO Act, 2012 are being made to address the aspects of child sexual abuse in an appropriate manner.   –  PopTika/shutterstock.com Published on Bombay HC upholds death penalty clause for repeat offenders in rape cases Cyber crime, cops and the law Children President signs Ordinance to provide death penalty for rapists of girls below 12 years The proposed changes in the Protection of Children from Sexual Offences (POCSO) Act also provide for fines and imprisonment to curb child pornography. The Union Cabinet has given its nod to amend certain sections of Protection of Children from Sexual Offences (POCSO) Act, 2012 to include provision of death penalty in cases of sexual offences against children.“The modification is made to address the need for stringent measures required to deter the rising trend of child sex abuse in the country on one hand and to address the menace of relatively new kind of crimes on the other hand,” Prakash Javadekar, Minister for Information & Broadcasting, told media persons.“Sections four, five and six are proposed to be amended to provide option of stringent punishment, including death penalty, for committing sexual assault and aggravated penetrative sexual assault crime on a child to protect the children from sexual abuse,” according to an official statement.Amendments are also proposed in Section 9 to protect children from sexual offences in times of natural calamities and in other situations where children are administered, in any way, any hormone or any chemical substance, to attain early sexual maturity for the purpose of penetrative sexual assault. Amendments are also proposed in Section 14 and 15 of the POCSO Act to levy fine for not destroying, deleting or reporting the pornographic material involving a child with an intention to share or transmit it.Amendment is proposed to be carried out in Section 2, 4, 5, 6, 9, 14, 15, 34, 42 and 45.last_img read more

With 100 members in attendance Lok Sabha sits till 1158 pm to

first_img Press Trust of India New DelhiJuly 12, 2019UPDATED: July 12, 2019 13:05 IST During the debate, the Opposition accused the Modi government of trying to sell off railways’ assets instead of focusing on services. (File Photo)The Lok Sabha sat till 11.58 pm on Thursday to conclude discussion on demands for grants for the Railway Ministry, with Parliamentary Affairs Minister Prahlad Joshi saying it is for the first time in nearly 18 years that the Lower House has sat for this long.Railway Minister Piyush Goyal is likely to reply to the debate Friday afternoon, following which the demands for grants will be put to vote.Nearly a 100 members participated in the debate which began Thursday afternoon and concluded at 11.58 pm.”It is a record,” Joshi said.During the debate, the Opposition accused the Modi government of trying to sell off railways’ assets instead of focusing on services, but the BJP asserted that the transport behemoth is breaking new ground everyday especially in areas of infrastructure and safety.The Congress, TMC and other parties tore into the government as they opposed alleged attempts to “privatise” the railways and claimed that the NDA dispensation was “selling dreams” like the ‘bullet train’ to the people, which were “not feasible”.Countering the opposition’s allegations, BJP MP Sunil Kumar Singh said the performance of railways is much better now than under the Congress rule and the national transporter was achieving new milestones.Railway accidents have reduced by 73 per cent in the five-year period of Modi government from 2014 to 2019, he noted.ALSO READ | 29 elected unopposed to Parliamentary Estimates panelALSO WATCH | Narendra Modi arrives for the first parliament session of 17th Lok SabhaFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySnigdha Choudhury Next With 100 members in attendance, Lok Sabha sits till 11.58 pm to conclude debate on railwaysParliamentary Affairs Minister Prahlad Joshi said it is for the first time in nearly 18 years that the Lower House has sat for this long.advertisementlast_img read more